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A combined model of human IPSC-derived liver organoids and hepatocytes reveals ferroptosis in DGUOK mutant mtDNA depletion syndrome

L-Arginine serves as a precursor to NO, which improves blood flow and oxygen delivery to tissues under stressful conditions [96]

The subcellular localization of these sources and the chemical nature of the species produced confer specificity to redox signaling, particularly through reversible oxidation of sensitive cysteines on target proteins